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體內(nèi)抗體——小鼠免疫細胞特異性耗竭抗體
In vivo antibodies——Mouse Immune Cell Specific Depletion Antibodies
In vivo Cell Specific
Depletion – T Cell, B Cell, NK Cells, and More
Mouse
Immune Cell Specific Depletion Antibodies | Leinco
Leinco
Technologies offers monoclonal antibodies to mouse cell specific surface
proteins and cytokines for in vivo cell specific depletion studies. Depletion can occur naturally (i.e. in HIV)
or be induced for treatment purposes. Therefore, it is a useful tool in
therapeutic, immunotherapy and diagnostic research. It is common practice for
researchers to use antibodies to remove a specific cell type to infer its
function, and mouse cell depletion in vivo experiments are used to establish
the role of specific cell types in a variety of immunological processes. As an
example, in vivo T cell depletion experiments using a combination of anti-CD4
(Clone GK1.5) and anti-CD8 (Clone 2.43 or 53-5.8) antibodies are efficient and
produce less deleterious effects on other blood cell populations compared to
using CD3 depletion antibodies (like clone 145-2C11 or 17A2) . Many of these
antibodies have been developed by academic and government labs all over the
world and have been reported and referenced for use in in vivo studies to
deplete a specific cell type (See the List below organized by clone and cell
type for depletion). Check out each clone’s datasheet for specific literature
references and information on dosage and product use.
Cell-Specific Depletion Antibodies from Leinco Technologies
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